Sunday, January 26, 2014

Psychotherapy for Plankton



http://mit.whoi.edu/student-research?tid=1423&cid=113369

Psychotherapy for Plankton

The scene: A diatom is out of its oceanic habitat and on a couch, talking to a therapist. The diatom is stressed. It can’t ever seem to get enough nutrients. And it’s feeling underappreciated ... 

Diatom: People just don’t seem to understand. Without me and all the other phytoplankton producing oxygen via photosynthesis, people wouldn’t have half the oxygen they need to breathe!  We’re also the base of the ocean food chain that supports the fish they eat, and all the carbon dioxide I take up from the air to make into my body would still be in the atmosphere, making the earth heat up. Why can’t they see how important I am?
Therapist: I’m hearing that you feel undervalued. Why do you think it is that people don’t understand?
Diatom: I suppose it’s because I’m so small. They can’t see me without a microscope, so I might as well not exist! But that’s not my main problem. I can go on fine without humans knowing how much they depend on me. The thing that’s really getting me down is all this stress I’m under. 
Therapist: Tell me what you mean. What’s causing this stress?
Diatom: Well, it’s a bit of a long story. I’ll start from the beginning. Since I do photosynthesis for a living, sunlight is my energy, and carbon dioxide from the atmosphere is my sustenance. But in order to grow, I need other ingredients, too, like nitrogen, iron, and vitamins. I use these ingredients in a specific ratio, just like a recipe. So, for example, even if there is plenty of nitrogen around in the ocean, unless there is also enough iron, I can’t grow. Whatever runs out first— that’s called a "limiting nutrient."
Therapist: I see. Why this is causing you such stress right now?
Diatom: So, I live in the Southern Ocean around Antarctica. The waters there have plenty of nitrogen for me to use, but there is almost never enough iron to go around. I have to compete with other phytoplankton for my iron, and I also have to compete with bacteria. It’s particularly annoying that I have to share this scarce resource with the bacteria, because the way theyget by in life is only through exploiting the carbon that we phytoplanktonmake for them. It just seems unfair!
Therapist: Correct me if I’m wrong, but it sounds to me like there’s more to this story.
Diatom: Uh, I suppose. My relationship with those bacteria—well, it’s complicated. Even though they take that scarce iron from me when I need it most, I just can’t live without them. When the bacteria grow and die, they release vitamin B12 into the water. I need that B12 to grow. And just like iron, it’s in short supply relative to the other ingredients I need. Without enough of those bacteria growing, I can’t get enough vitamin B12. Without enough iron or B12, I get really stressed! It’s just a bad cycle.
Therapist: It seems almost like sibling rivalry. You and the bacteria are dependent on each other, but at the same time, you’re also competing with each other for iron. That’s quite a delicately balanced relationship you have to negotiate there in the Southern Ocean. What are some strategies you use to try to cope with this stress?
Diatom: Life really gets difficult for me when I start to get starved for iron or vitamin B12. First, I try harder to get these missing nutrients. I make more of proteins that I use to find and transport the iron or vitamin from the seawater into my cell. I also make more of the proteins that I need to move the iron or vitamin around inside my cell. This way, as soon as I find the nutrients I need, I’m ready to use them. 
Therapist:  These seem like good strategies. But what happens if they don’t work?
Diatom: Well, I try to get by with less of whatever I’m feeling starved for. Sometimes I can substitute some other nutrient for the scarce ones, but this doesn’t always work very well. I just can’t work as efficiently when I’m starved, but I can make do and grow more slowly for a while. If supplies of these nutrients are too low, I just won’t survive. You can see why this is causing me such anxiety.
Therapist: Yes, your reaction seems perfectly natural. Let’s try to think of ways to manage this stress.  Are there any ways you could predict what nutrients you are going to be starved for?
Diatom:  Well, I’m not sure. I know that oceanographers are looking into this, too. They want to know what nutrients starve me and the other phytoplankton. But they don’t seem much better than me at predicting which nutrients are limiting how much we can grow. Until a couple of years ago, the scientists weren’t even sure we could be limited by the lack of vitamin B12!
Therapist: That’s interesting. Go on.
Diatom: One way scientists find out about what controls our growth is to take some of us out of the ocean, put us in bottles, add different nutrients, and watch to see which make us grow faster. This doesn’t make a lot of sense to me, because I know that being in a bottle can make us plankton respond to nutrients differently than we do growing in the ocean. There just has to be a better way.
Therapist: Yes, yes. But I’m afraid we are out of time; let’s pick this up again next session.
The following week.
Therapist: I did some research after last week’s session and found something that may help. It seems that some scientists are actually finding new ways to learn about what starves you phytoplankton. Really. The way they are doing this is by looking closely at changes in the way you grow when you are starved for specific nutrients, particularly vitamin B12. They are just learning how to measure those coping strategies you told me about last week. They have developed new technologies that allow them to detect and measure the proteins that organisms make when they are grown under different conditions. 
Diatom: Are you saying that ocean scientists think they can tell when we phytoplankton feel starved for B12 just by watching what kinds of proteins we make? They actually are interested enough in phytoplankton to make new methods to do this?
Therapist: That’s right. When the scientists grew some of you in the laboratory, they noticed that there were a few proteins that you make moreof when you are starved for the vitamin, but not when you are starved for other nutrients. They call these proteins “B12-starvation indicator proteins.” 
Diatom: They come up with fancy names, those scientists. If only they could learn how to measure those—what did they call them, B12 … starvation indicator proteins?—if only they could measure them in the ocean instead of just in the lab! If they did, they could figure out what controls all the patterns and processes that lead to us getting starved for vitamin B12. I’d sure love to know that. Then I could be prepared for the stress.  That would make life so much easier!
Therapist: I know that they are doing their best. In order to use these measurements to learn about what stresses you, the scientists will need to measure these proteins from within a very complex mixture of many thousands or even millions of other proteins in the ocean, and they must also be sure they understand why you make this protein. They are getting closer!
Diatom: Wow, that’s great news. I feel a little better already. It’s comforting to think that those scientists aren’t overlooking me and care so much about me and my stress!
This research was supported by National Science Foundation (NSF) Graduate Research Fellowship and an Environmental Protection Agency STAR Fellowship, the WHOI Ocean Ventures Fund, the NSF Ocean Sciences Division and Office of Polar Programs, and the Gordon and Betty Moore Foundation.
About the author: Erin Bertrand has worked to measure nutrient stress in diatoms in Mak Saito’s lab in the WHOI Marine Chemistry and Geochemistry Department, as part of her research for her Ph.D. from the MIT/ WHOI Joint Program in Oceanography. She  has been interested in how the availability of metals in the environment affects microscopic organisms ever since she started conducting research as an undergraduate at Bates College. When she is not growing diatoms, extracting proteins, taking samples of phytoplankton in Antarctica, or running the mass spectrometer, she likes to hike or run in the woods, listen to live music, or cook something new for her friends and family. Her mentor on this article was Heather Goldstone, a science journalist for WCAI radio (and a graduate of the MIT/WHOI Joint Program).
By Erin Bertrand
MIT/WHOI Joint Program in Oceanography
Marine Chemistry & Geochemistry Dept.

Wednesday, January 22, 2014

Sampath Kumar wins award for Rechargeable Alkaline Zinc Battery


Sampath Kumar wins award for Rechargeable Alkaline Zinc Battery

http://www.tifac.org.in/index.php?option=com_content&view=article&id=904:national-award-to-commercializable-patents-2013-14&catid=49:latest-news&Itemid=17

Technology Refinement and Marketing Programme (TREMAP)
List of Final Stage Selection of Patents for
National Award to Commercializable Patents 2013-14

Sl. No.Patent Title
Name of Patent Holder
Patent Title No.
 1.
A nanosized electrochemical dispersion for rechargeable alkaline zinc batteries Sh. Thothathri Sampath Kumar 246506